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A square of John Wayne Casserole on a black plate.
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5 from 2 votes

Beefy John Wayne Casserole

Beefy, cheesy, spicy, and with a Bisquick base, John Wayne Casserole is just about the perfect casserole!
Prep Time15 minutes
Cook Time35 minutes
Total Time50 minutes
Course: Casseroles, Main Course
Cuisine: American
Keyword: breakfast casserole, ground beef, john wayne casserole, vintage casserole
Servings: 8 servings
Calories: 760kcal
Author: Chef Jenn

Ingredients

Instructions

  • Preheat your oven to 375-F and spray a 9x13-inch baking dish with nonstick cooking spray. Set this aside.
  • Combine the Bisquick mix with 1 cup of water in a large bowl. Mix until combined. Set aside.
  • Add the onions and cooking oil to a large skillet and cook over medium heat for 4-5 minutes or until the onion starts to soften.
  • Add the ground beef to the onions and continue to cook, breaking it up as it cooks. Drain off the fat.
  • Add the cumin, chili powder, garlic powder, onion powder, and a good pinch of salt and pepper to the ground beef and mix well. Cook for 2-3 minutes more, then transfer the beef mixture to a bowl and set aside
  • Combine the drained Rotel tomatoes, diced bell peppers, corn niblets, fresh tomatoes, and canned green chilies in the same skillet and mix well to combine. Heat over medium heat until heated through.
  • Combine the softened cream cheese, mayonnaise, and 2 cups of cheddar cheese in a bowl until well mixed.
  • Spread the Bisquick-water mixture into the bottom of your prepared baking dish. Use an offset spatula to help spread it around into an even layer.
  • Top with the ground beef mixture.
  • Top with the vegetable mixture.
  • Spread the cream cheese, mayo, and cheddar mixture over the top and finish by sprinkling the rest of the cheddar cheese over the top.
  • Bake at 375-F for about 30-35 minutes or until the baking mix has set on the bottom and the casserole is hot.

Notes

Chef Jenn's Tips
  • You can use any ground meat in this recipe. Try it with ground turkey or chicken, or even sausage.
  • I love a dollop of sour cream on top - it adds a pop of freshness!
  • Don't hesitate to customize the spice levels to your liking. More chili powder or a dash of cayenne pepper can kick it up a notch.

Nutrition

Serving: 1cup | Calories: 760kcal | Carbohydrates: 40g | Protein: 27g | Fat: 55g | Saturated Fat: 22g | Polyunsaturated Fat: 9g | Monounsaturated Fat: 18g | Trans Fat: 1g | Cholesterol: 118mg | Sodium: 1152mg | Potassium: 488mg | Fiber: 3g | Sugar: 9g | Vitamin A: 1542IU | Vitamin C: 30mg | Calcium: 445mg | Iron: 3mg